Investigating the prevalence and antimicrobial resistance patterns of Pseudomonas aeruginosa in Cameroon: A systematic review and meta-analysis
Keywords:
Pseudomonas aeruginosa, resistance, antibiotics, epidemiology, clinical isolates.Abstract
Background: Pseudomonas aeruginosa is a non-fermentative bacteria which present a rapid increase in
the rates of infections across the world. Pseudomonas aeruginosa ranks third among the resistant
bacteria responsible for nosocomial infections. Aim: To assess the distribution and evolution of
resistance of Pseudomonas aeruginosa in Cameroon. Methods: We carried out a systematic review of
the research publications that determined the resistance phenotypes of Pseudomonas aeruginosa in
Cameroon. A meta-analysis of the data was carried out to synthesize the data on resistance
phenotypes, their distribution and their evolution in Cameroon. Results: A considerable increase in
resistance to ceftazidime, aztreonam, gentamycin and tobramycin between 2005 and 2011 was
observed. In addition, an increase in resistance to imipenem was noted between 2011 and 2013. The
city of Douala has a high frequency of Pseudomonas aeruginosa followed by Buea and Yaounde.
Conclusion: Pseudomonas aeruginosa has a high frequency and resistance to several antibiotics in
Cameroon. There is a need to continue surveillance in several hospitals and in several regions of
Cameroon in order to implement policies and measures to fight infections and antibiotic resistance.
