Salvia sahendica prevents tissue damages induced by alcohol in oxidative stress conditions: Effect on liver and kidney oxidative parameters

Abstract

Oxidative stress plays an essential role in the development of alcohol liver disease. The present study
represents the protective effect of a polyphenolic rich extract of Salvia sahandica against liver and kidney
damages in alcohol-induced oxidative stress. Measurement antioxidant activity by scavenging of 1,1-diphenyl-2-
picrylhydrazyl radical showed that methanolic extract of S. sahendica possesses the highest antioxidant
activity. Treatment of experimental rats with ethanol for one month showed an increase in activities of liver
marker enzymes, lipid peroxidation marker (TBARS) with significantly lower activity of enzymatic and nonenzymatic antioxidants in rat liver and kidney compared to those in normal rats. Treatment alcohol rats with S.
sahendica at a dose of (0.1 g/kg) significantly reduced the level of lipid peroxidation and liver marker enzymes
and restored the enzymic and non-enzymatic antioxidants levels in liver and kidney of treated rats. The results
of this study strongly indicate that S. sahendica has potent hepato-protective effect against alcohol induced
tissues damage in experimental animals. This study also suggests that possible mechanism of this activity may
be due to the presence of flavonoids and phenolics compound(s) in the methanolic extract of S. sahendica
which may be responsible to hepato-protective activity.