Toxicological renal effects of Bridelia ferruginea-treated wastewater in rats

Abstract

The effect of wastewater fed to rats following treatment with a 2.5% (w/v) methanolic crude extract of
Bridelia ferruginea for different times (0 to 96 h) was investigated. Kidneys of rats fed with the treated
wastewater was subjected to histological examination and compared to negative (rats given wastewater
treated with methanol alone), positive (rats given untreated wastewater alone) and standard (rats given
sterile distilled water alone) control groups. Histopathological findings revealed extensive damage in
the tissues of rats assigned to the negative, positive and B. ferruginea extract-treated groups. However,
no damage was observed in the tissues of the standard control group. The potential efficacy and the
toxicological renal effects of B. ferruginea extract-treated wastewater is discussed.