A study on antimicrobial resistance of urinary tract isolated Esherichia coli from Omdurman Teaching Hospital in Sudan

Abstract

Infections caused by Escherichia coli have become a significant worldwide public health problem. The
antibiotic resistance of E. coli isolated from the urine of patients of Omdurman Teaching Hospital,
Sudan was investigated. The aim of this study was to evaluate the antimicrobial sensitivity of all the non
serotyped urinary isolated E. coli. The antibiotic sensitivity test was carried out using antibiotic
impregnated multi disc containing eight different antibiotics (Amikacin, Ciproflaxacin, Ceftriaxone, Coamoxiclav, Imipenem, Norfloxacin and Cotrimoxazole). A total of eighty-six E. coli isolates were tested
during the investigation. The E. coli isolated exhibited variations in their resistance pattern to the
various antibiotics. Generally, no E. coli was resistant to all tested antibiotics, no E. coli isolate was also
resistant to only one or a single antibiotic and only two isolates were completely sensitive to all the
antibiotics used. The E. coli showed the highest resistance to Cotrimoxazole, Co-amoxiclav, Ciprofloxacin and Norfloxacin. Antimicrobial resistance is a local as well as a global problem and the
emergence of multidrug resistance will hinder the therapeutic options, hence monitoring resistance is
of paramount importance. The indiscriminate use and misuse of antibiotics should therefore be
discouraged. The future usefulness of these drugs will however depend on effective interventions to
halt the selection and spread of resistance among enteric organisms.