Investigating the potential antidiabetic properties of 7-Methoxycoumarin derived from the bark of marine plant Rhizophora mucronata

Abstract

Coumarin possess a number of biological activity like anticoagulant, antimicrobial, anti-inflammatory, analgesic, antioxidant, anticancer, antiviral, antimalarial etc. But the antidiabetic property of coumarins from marine plants are not attempted so for and hence, the present study has been carried out. The present study isolated a coumarins from the bark of Rhizophora mucronata. This coumarins belongs to a group as benzopyrones, which consists of a benzene ring joined to a pyronenucleus and confirmed by IR, ¹H-NMR, ¹³C-NMR and mass spectral studies. The present work deals with the isolation, characterization and antidiabetic activity of in vivo study of this compound. The isolated compounds have been identified as 7- methoxy coumarins and further, the isolated coumarins were subjected for the in vivo antidiabetic activity and it reveals that, the 7-methoxy coumarins potentiate antidiabetic activity.