Effect of ethanol leaf extract of Millettia aboensis on selected haematological indices of Wistar albino rats

Abstract

Phytochemical screening of crude leaf extract of Millettia aboensis showed the presence of reducing sugar,
alkaloids, flavonoids, saponins, tannins, Phlobatannins and cardiac glycosides and the absence of cyanogenic
glycoside and anthraquinone. Effect of ethanol leaf extracts of M. aboensis on haematological parameters was
evaluated in thirty Wistar albino rats consisting of six groups (5 rats per group). Groups were administered with
1000, 2000, 3000, 4000 and 5000 mg/kg body weight of the extract and group 6 (positive control) was given
normal food and water. The results showed that the haematological parameters of packed cell volume (PCV),
haemoglobin concentration of the cell (Hb), total white blood cell counts (WBC) and platelets count of the rats
administered with ethanol leaf extract of M. aboensis increased significantly (p<0.05) in groups 5 (5000 mg/kg
body weight of the extract), group 4 (4000 mg/kg body weight of the extract) and group 3(3000 mg/kg body
weight of the extract) compared to group 6 (positive control). Group 2 (2000 mg/kg body weight of the extract),
group 1 (1000 mg/kg body weight of the extract) showed no significant difference (p>0.05) in haematological
parameters of packed cell volume (PCV), haemoglobin concentration of the cell (Hb), total white blood cell
counts (WBC) and platelets count of the rats administered with ethanol leaf extract of M. aboensis compared to
group 6 (positive control).