Analysis of codon usage in peste des petits ruminant’s virus

Abstract

In this study, it is indicated that the bias of synonymous codon usage of Peste des Petits Ruminants
virus (PPRV) gene is lower without intra-specific performance through analysis on PPRV gene
synonymous codon usage. The virus has interspecies codon usage specific performance in
Morbillivirus. PPRV synonymous codon usage pattern is mainly caused by genetic base, the changes of
codon usage bias are mainly caused by pressure of gene mutations. Meanwhile, the gene function also
determines PPRV codon usage to some extent. However, the gene length and translation stress have
no influence on codon usage patterns in genes of the virus. The codon usage bias pattern of PPRV that
we analyzed plays an important role for understanding the evolution process of the virus, in particular
to understanding the role of mutation and selection in this process.