Effects of aqueous leaves extract of Ocimum gratissimum on blood glucose levels of streptozocin-induced diabetic wistar rats

Abstract

The hypoglycemic effects of aqueous leaves extract of Ocimum gratisimum was investigated in streptozocin-induced
diabetic rats. A single administration of the extract at the doses of 250, 500 and 1000 mg/kg body weight was done.
The aqueous extract at the dose of 500 mg/kg significantly lowered blood glucose level (P<0.05) of the diabetic rats
by 81.3% after 24 h of extract administration. Preliminary phytochemical screening revealed the presence of reducing
sugars, cardiac glycosides, resin, tannins, saponins, glycosides, flavonoids, glycerin and steroids. The median lethal
dose (LD50) in rats was calculated to be 1264.9 mg/kg body weight. In conclusion, the leaves extract of O. gratissmm
possess antidiabetic in streptozocin-induced in diabetic rats.