Evaluation of the anti-edematogenic activity of the aqueous extract of Leea guineensis

Abstract

Leea guineensis leaf is a medicinal herb used in folk medicine for the management of inflammatory
disease conditions such as in splenomegaly in children. Because of this use, the plant was evaluated
for anti-inflammatory properties. The phytochemical studies revealed the presence of saponins and
glycosides as the secondary metabolites. Using the carrageenan- induced paw oedema, there was a
significant (P<0.001) reduction in edema. The study also revealed a dose dependent anti-edematogenic
activity. These preliminary investigations seem to support its use by herbalists to treat inflammatory
disease condition such as splenomegaly.