Assessing Oral Melatonin for Prevention of Postoperative Delirium in Patients Undergoing Elective Surgery

Abstract

Background: Postoperative delirium is a frequent complication following elective surgery under
general anesthesia, associated with increased morbidity, prolonged hospital stay, and long-term
cognitive decline. Melatonin, a neurohormone with antioxidant, anti-inflammatory, and circadian-
regulating properties, has emerged as a potential preventive strategy.
Aim: To evaluate the efficacy of a single 3 mg oral dose of melatonin administered the night before
surgery in reducing the incidence of postoperative delirium and improving perioperative outcomes.