ΙL-8 and MCP-1 in children with acute lymphoblastic leukemia and potential correlation with neurotoxicity and thromboembolic phenomena
Keywords:
acute lymphoblastic leukemia, children, neurotoxicity, thrombosis, methotrexate.Abstract
Our purpose was to report the safety of methotrexate in children with acute lymphoblastic leukemia treated
with the Berlin-Frankfurt-Münster-95 protocol. We also determined whether serial blood assessment of
vitamin B12, folate, methotrexate, homocysteine, IL-8 and MCP-1 along with cerebrospinal fluid
measurement of IL-8 and MCP-1 had any correlation with neurotoxicity and thromboembolic incidents. Out
of 16 patients, 2 exhibited seizures, whereas 1 exhibited central retinal artery occlusion. Due to the small
number of patients no robust conclusions could be drawn. More studies are needed so as to determine
whether these biological parameters could be used as markers for toxicity.
