Synthesis of Azalactones involving the use of sodium acetate, anhydrous, KPO4 and calcium acetate
Keywords:
Azalactone,, benzoxazinone,, quinazolinone,, fused pyrimidinopyrimidine,, 1,3,4-thiadiazolopyrimidine, Schiff’s base.Abstract
Azalactone 1 can be synthesized via treatment of 4- chlorobenzoyl glycine with p-anisaldehyde in the
presence of acetic anhydride and sod Acetate. The behaviour of azalactone 1 towards nitrogen nucleophiles,
for example, anthranilic acid, 6-aminopyrimidin-2,4-dione and 2-amino-6-phenyl 1,3,4-thiadiazole can be
investigated. Benzoxazone 2 can be treated with hydrazine hydrate, hydroxylamine hydrochloride, and ophenylenediamine in different reaction conditions to afford quinazolinone derivatives 3, 4, 5, 6. The
imidazoloquinazolinone derivative 6 can be treated with hydrazine derivatives.
Pyrimidino/thiadiazolopyrimidine 8, 11 can be treated with acetic anhydride to increase their biological
activities. The structures of all synthesized compounds were confirmed from analytical as well as spectral
data.
