Quantitative changes of serum immunoglobulins A, G and M among patients with Hepatitis A

Abstract

There is evidence of change in the level of serum immunoglobulins (Ig) in patients with hepatitis A and
attempts for these changes to be associated with the clinical course of the disease. The aim of this study
is to establish the quantitative changes of IgA, IgG and IgM in hepatitis A patients and to evaluate their
significance for the clinical course of the disease. A total of 125 persons were examined: 35 patients with
prolonged form of HAV; 51 patients with self limited form of HAV; 35 healthy persons – control group. In
comparison with the control group, a substantial increase of IgA, IgG and IgM was found in patients with
prolonged form of HAV. In patients with self limited form of HAV, the increase was significant for IgG and
IgA, and insignificant for IgM. The research on serum Ig supplements the research panel performed for
patients with HAV and may have prognostic importance in determining the severity of the disease and the
prolonged forms of HAV